For laboratory research use only. Not for human, clinical, diagnostic, or therapeutic use.
Mitochondrial-Derived Peptide
MOTS-c
Synonyms: Mitochondrial open reading frame of the 12S rRNA-c · MRWQEMGYIFYPRKLR
Synthetic 16-residue mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA. Sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg. Lyophilized powder for reconstitution.
Fill weight
10 mg
$25.00
● IN STOCK
Technical specifications
Compound data
MOLECULAR DATA
Structural profile
ClassMitochondrial-derived peptide (MDP)
SequenceMet-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Residues16
FormulaC₁₀₂H₁₅₈N₃₀O₂₄S₂
Mol. weight~2174.6
PubChem Database → BIOLOGICAL ORIGIN
Parent molecule & position
Derived fromMitochondrial 12S rRNA — encoded by a small open reading frame (sORF) within the MT-RNR1 gene on mitochondrial DNA
Parent lengthN/A — full-length encoded peptide from a mitochondrial sORF (16 residues total)
PositionEncoded within the 12S rRNA gene (MT-RNR1) of mitochondrial DNA, bases ~1342–1392
Receptor associationNo defined cell-surface receptor; functions intracellularly through AMPK signaling and reported nuclear translocation under metabolic stress
Lee C et al · MOTS-c metabolic regulation · 2015 · Cell Metabolism →
HANDLING & STORAGE
Storage parameters
LYOPHILIZED
−20°C
Store sealed and protected from moisture. Stable at −20°C until reconstitution.
IN SOLVENT
2–8°C
Once reconstituted with bacteriostatic water, refrigerate. Use within 4 weeks.
LIGHT
SHIELD
Protect from direct light during storage and handling.
Bibliographic references
Literature cited
CELL METAB · 2015
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
25738459
Research use notice
This product is sold for in-vitro laboratory research use only. It is not intended for use in humans, not intended for diagnostic use, and not intended for therapeutic applications. This product is not a drug, food, cosmetic, dietary supplement, or medical device, and has not been evaluated by the FDA for any use.
Any scientific literature referenced on this page is provided as bibliographic context for the compound's published research history. Citations do not constitute claims regarding the properties, effects, or applications of this product, and Biovexia LLC makes no representation regarding outcomes of any research conducted with this product.
Purchaser is responsible for compliance with all applicable federal, state, local, and institutional regulations governing the handling, storage, and use of research chemicals.
Any scientific literature referenced on this page is provided as bibliographic context for the compound's published research history. Citations do not constitute claims regarding the properties, effects, or applications of this product, and Biovexia LLC makes no representation regarding outcomes of any research conducted with this product.
Purchaser is responsible for compliance with all applicable federal, state, local, and institutional regulations governing the handling, storage, and use of research chemicals.